Technology

Our biochip is a versatile, cutting-edge biosensing platform that deeply integrates microfluidics with semiconductor technology, enabling rapid and highly sensitive detection of trace amounts of DNA, RNA, proteins, antibodies, pathogens, and any other biomolecular fragments.

Our core technology is the Silicon Nanowire Field-Effect Transistor (SiNW-FET) chip, developed based on Bio-FET (Biological Field-Effect Transistor) technology. This label-free and amplification-free sensor combines nanowires with biological probes to detect pA-level ultra-trace current changes caused by probe–analyte binding events, enabling ultra-high-sensitivity detection.

Features of Bio-FET

High Surface-to-Volume Ratio

Using a nanoscale design to maximize contact with biomolecules to boost sensitivity.

Label-Free Detection

Detects molecular binding directly without fluorescent or enzymatic labels to simplify workflows.

Amplication Free

No PCR or amplification required, yet accurately detects ultra-low concentration samples for clinical and liquid biopsy use.

Real-Time Detection

Provide real-time binding signals for dynamic monitoring and rapid testing.

Compact Design

Enable easy integration with portable devices for on-site diagnostics.

Bio-FET vs. Traditional Methods

Feature Bio-FET Chip PCR ELISA
Requires Labeling No Yes Yes
Time to Result < 0.5 hours 1–4 hours 2–5 hours
Real-Time Detection Yes No No
System Integration High Low Low

Bio-FET technology drastically reduces time, complexity, and cost compared to conventional PCR and ELISA, making it ideal for point-of-care diagnostics and automated workflows.

Applications

Our biochips can be widely applied in various medical and defense settings, with rapid deployment capability in airports, seaports, forward operating bases, and other high-security or public venues, to identify carriers or implement preventive isolation before infected individuals become contagious:

✓ Infectious Disease Diagnostics (e.g., COVID-19, influenza)

✓ Cancer Biomarker Detection for early screening

✓ Drug Resistance Profiling (e.g., Antibiotics)

✓ Rapid bacteria classification without culture

✓ Environmental and Food Safety Testing

✓ Neurodegenerative Disease Research (e.g., Alzheimer’s)

Scientific Publications

Recent Advances in Field Effect Transistor Biosensors: Designing Strategies and Applications for Sensitive Assay

Authors:

Ruisha Hao, Lei Liu, Jiangyan Yuan, Lingli Wu, Shengbin Lei

Journal:

Biosensors, 2023, 13(4), 426

Ion-sensitive field effect transistor biosensors for biomarker detection: current progress and challenges

Authors:

Jie Zou, Hao Bai, Limei Zhang, Yan Shen, Chengli Yang, Weihua Zhuang, Jie Hu, Yongchao Yao, Wenchuang Hu

Journal:

Journal of Materials Chemistry B, 2024, Issue 35

Field-Effect Transistor Biosensors for Biomedical Applications: Recent Advances and Future Prospects

Authors:

Cao-An Vu, Wen-Yih Chen

Journal:

Sensors, 2019, 19(19), 4214

Advances in field effect transistor based electronic devices integrated with CMOS technology for biosensing

Authors:

Harshita Rai, Kshitij RB Singh, Arunadevi Natarajan, Shyam S. Pandey

Journal:

Nano Materials Science, 2024